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|Sermaglutide, Semaglutide Acetate Salt
|2mg, 5mg, 10mg/ Vial
|1 Kit (10 Vials)
Cosmetic Peptide Semaglutide 2mg 5mg Sermaglutide 10mg Vials for Weight Loss
The most recently approved GLP-1RAs is semaglutide. This agent is somewhat special among GLP-1RAs given that it is the only drug available as both subcutaneous injection (similar to all other GLP-1RAs) and as an oral formulation. Moreover, with years of development after marketing approval of the first GLP-1RA, the registration trials with semaglutide could focus on the already known potential safety risks of this drug class. In this review, as part of a supplement on semaglutide, we will detail the safety aspects of this drug.
Semaglutide has been developed based on the vast body of research behind the development of liraglutide . Compared to liraglutide, which is administered once daily, semaglutide has an even longer half-life, allowing for once weekly administration. While a significant improvement over once or twice daily subcutaneous administration, the injecting route could be a barrier for some potential users. An absorption enhancer was discovered (sodium N-[8-(2-hydroxybenzoyl) aminocaprylate] or SNAC), which, when co-administered with semaglutide, was demonstrated to give therapeutic levels of the latter (8). SNAC helps to protect semaglutide from proteolytic degradation in the stomach and facilitates its absorption across the gastric mucosa by transient effects on transcellular pathways . At equivalent levels of exposure, similar glycemic and weight responses have been seen with both oral and subcutaneous semaglutide.
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